2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W702908
    DM-4107 1346599-75-4 98%
    DM-4107 is a major metabolite of Tolvaptan (HY-17000) that is metabolized primarily by the CYP3A4 enzyme in the liver. DM-4107 inhibits the ability of human liver transporters NTCP, BSEP, MRP3, MRP4 (IC50 values are 95.6, 119, 61.2, 37.9 μM, respectively) and bile acid transport in SCHH cells. DM-4107 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD).
    DM-4107
  • HY-W703629
    Acetohexamide-d11 2468796-77-0 98%
    Acetohexamide-d11 is the deuterium labeled Acetohexamide (HY-B0881). Acetohexamide is a first-generation sulfonylurea agent used in research related to type 2 diabetes; it stimulates the pancreas to secrete insulin.Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas.
    Acetohexamide-d11
  • HY-W704031
    Prasugrel metabolite 1 239466-86-5 98%
    Prasugrel metabolite 1 (M7 (R-119251)) is one of the inactive metabolites of Prasugrel (HY-15284) in the human body.
    Prasugrel metabolite 1
  • HY-W704677
    Palmityl stearate 1190-63-2 98%
    Palmityl stearate (Cetyl stearate) is an ester product.
    Palmityl stearate
  • HY-W704878
    (Z)-Entacapone-d10-1 1185241-19-3 98%
    (Z)-Entacapone-d10-1 is the deuterium labeled (Z)-Entacapone (HY-139089). (Z)-Entacapone is a metabolite of the catechol-O-methyltransferase (COMT) inhibitor Entacapone (HY-14280). It is also a potential impurity found in commercial preparations of Entacapone and a degradant of Entacapone formed by UV light exposure.
    (Z)-Entacapone-d10-1
  • HY-W705452
    4-Palmitamido-TEMPO 22977-65-7 98%
    4-Palmitamido-TEMPO is an aliphatic derivative of TEMPO. It is incorporated into vesicles and cell membranes and has been used to study the entrapment of molecules in phosphatidylcholine vesicles.
    4-Palmitamido-TEMPO
  • HY-W707119
    RepSox hydrochloride 2319939-07-4 98%
    RepSox hydrochloride is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5). RepSox hydrochloride inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox hydrochloride can be used in the study of obesity and related metabolic diseases such as type 2 diabetes.
    RepSox hydrochloride
  • HY-W707358
    12-Hydroxydodecanoic acid-d20 2733155-23-0 98%
    12-Hydroxydodecanoic acid-d20 is the deuterium labeled 12-Hydroxydodecanoic acid (HY-128743). 12-Hydroxydodecanoic acid is an endogenous metabolite.
    12-Hydroxydodecanoic acid-d20
  • HY-W707562
    FOY 251-d4 2733723-91-4 98%
    FOY 251-d4 is the deuterium labeled FOY 251 (HY-19727A). FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay.
    FOY 251-d4
  • HY-W707564
    Atorvastatin-d5-1 sodium 98%
    Atorvastatin-d5-1 sodium is the deuterium labeled Atorvastatin sodium (HY-108257). Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
    Atorvastatin-d5-1 sodium
  • HY-W707656
    Aspirin-d7 98%
    Aspirin-d7 is the deuterium labeled Aspirin (HY-14654). Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis.
    Aspirin-d7
  • HY-W709047
    Orlistat impurity-M3 98%
    Orlistat impurity-M3 is a Orlistat (HY-B0218) degradation product. Orlistat is a well-known irreversible inhibitor of pancreatic and gastric lipases.
    Orlistat impurity-M3
  • HY-W710927
    L-2-Aminobutyric acid-d5 98%
    L-2-Aminobutyric acid-d5 is the deuterium labeled H-Abu-OH (HY-W010589). H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
    L-2-Aminobutyric acid-d5
  • HY-W711286
    N-Methylethanolamine phosphate 6909-61-1 98%
    N-Methylethanolamine phosphate is a nucleoside metabolite.
    N-Methylethanolamine phosphate
  • HY-W711807
    D-Arabitol-d7 2377475-83-5 98%
    D-Arabitol-d7 is the deuterium labeled D-Arabitol (HY-N3686). D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.
    D-Arabitol-d7
  • HY-W712673
    2-Methylacetoacetyl-CoA 6712-01-2 98%
    2-Methylacetoacetyl-COA (2-Methylacetoacetyl-coenzyme A) is a 3-oxoacyl-CoA.
    2-Methylacetoacetyl-CoA
  • HY-W712675
    3-Hydroxy-2-methylbutyryl-CoA 6701-38-8 98%
    3-Hydroxy-2-methylbutyryl-CoA (3-Hydroxy-2-methylbutyryl-Coenzyme A) is a coenzyme A derivative.
    3-Hydroxy-2-methylbutyryl-CoA
  • HY-W712676
    Methacryloyl-CoA 6008-91-9 98%
    Methacryloyl-CoA (Methacrylyl-coenzyme A) is a coenzyme A derivative.
    Methacryloyl-CoA
  • HY-W712932
    Chenodeoxycholic Acid-d7 98%
    Chenodeoxycholic Acid-d7 (CDCA-d7) is the deuterium labeled Chenodeoxycholic Acid (HY-76847). Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
    Chenodeoxycholic Acid-d7
  • HY-W714006
    Cochliodinol 11051-88-0 98%
    Cochliodinol (compound 1) is a metabolite derived from the Apis mellifera ligustica. Cochliodinol has strong free radical scavenging activity of 2, 2-diphenyl-1-picrohydrazine (DPPH) (IC50=3.06 μg/mL).
    Cochliodinol
Cat. No. Product Name / Synonyms Application Reactivity